O. David Sparkman Analytical
Chemistry
Adjunct
Professor
E-mail: osparkman@pacific.edu
Work phone: (209) 483-5740
Office Location: CR #118
Personal Link: http://www1.pacific.edu/~osparkma
___________________________________________________________________________
Research Interest: Instrumental analysis, mass spectrometry, gas-phase ion chemistry, mass spectral databases and searches, collaborations with Dr. Patrick R. Jones.
JEOL LCmate (LC-MS) Shimadzu/Kratos AXIMA
Recipient of the 2008 American Chemical Society Analytical Chemistry Division’s
Award for Distinguished Service in the Advancement of Analytical Chemistry.
At Pacific, Professor Sparkman
teaches a graduate course in mass spectrometry and has taught undergraduate
analytical chemistry. He is the manager
of the Pacific Mass Spectrometry
Facility. He is also the author of Mass Spectrometry Desk Reference, 2nd
ed. (2006, Global View Publishing, Pittsburgh, PA, ISBN: 978-0-9660813-2-9);
the coauthor of Introduction to Mass
Spectrometry: Instrumentation, Applications, and Strategies for Data
Interpretation, 4th ed. (2007, John Wiley & Sons, Chichester,
U.K., ISBN: 978-0-470-51634-8) with J. Throck Watson,
Professor Emeritus, Department of Chemistry and Department of Biochemistry,
Michigan State University; and co-designer with Watson of the Mass Spectrometry Quick Reference Guide,
which has been translated from English into French, German, and Spanish and
published by multiple mass spectrometry manufacturers. Every year since 1995, Professor Sparkman has
published “What’s New in Mass Spectrometry at PittCon”, a review of new
products and technology presented at the annual Pittsburgh Conference on
Analytical Chemistry and Applied Spectroscopy in the Journal of the American Society for Mass Spectrometry. In addition, he taught 2-day and 3-day
courses in the interpretation of mass spectra, GC/MS, and LC/MS for the
American Chemical Society from 1978 to 2006.
He now teaches these same courses for LC Resources. Professor Sparkman is the director of Chromatography/Mass Spectrometry: Principles
and Practice, which is a 5-day intensive hands‑on course
taught every summer at Pacific using the latest instrumentation provided by the
various manufacturers. Professor
Sparkman is currently, and has been for the past 15 years, a consultant to the
The Mass Spectrometry Facility at Pacific currently has a JEOL GCmate double‑focusing mass spectrometer with EI, CI, and LINK scan capability, and a Resolving Power of 5000 (10% valley) at maximum sensitivity; a JEOL LCmate with APCI and electrospray interfaces, LINK scan capability, and a Resolving Power of 5000 (FWHM); a Shimadzu/Kratos AXIMA CFR Plus MALDI/Curved Field Reflectron TOF, R=20,000; a Varian Saturn IV quadrupole ion trap GC‑MS with EI, CI, SIS, and MS/MS options; a Varian 1200L triple quadrupole with ESI and APCI; a Varian 4000 GC‑MS; a Varian 2000 GC‑MS; an Agilent 6890/5975 GC‑MS; A Varian 320 triple quadrupole with ESI; a Shimadzu QP 2010 LC‑MS with ESI; and a JEOL AccuTOF with ESI, APCI, and DART.
Professor Sparkman’s research interests include the use of electron ionization mass spectral databases in the interpretation of spectra generated from other ionization techniques and MS/MS and fragmentation mechanisms. He is also very interested in the development of forensic applications of DART ionization and the mechanisms of DART ionization.
Recent publications and presentations
Matthew E. Curtis, Patrick R. Jones, O. David Sparkman, Robert B. Cody “Determination of the Presence or Absence of Sulfur Materials in Drywall Using Direct Analysis in Real Time in Conjunction with an Accurate-mass Time-of-Flight Mass Spectrometer” J. Am. Soc. Mass Spectrom. 2009, 20 in press.
Jianping Chen1; O. David Sparkman2; Ming Gu3, 1Connecticut State Department of Environmental, Windsor , CT; 2University of the Pacific, Antioch, CA; 3Cerno Bioscience, Yardley, PA “Confident Unknown Identification of SVOC Compounds by Combining NIST Library Search with Elemental Composition Determination” Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics; Philadelphia, PA, 2009.
Valeri I Babushok2; Stephen E. Stein2; Igor Zenkevich3; Peter Linstrom2; O. David Sparkman1 1University of the Pacific, Antioch , CA; 2NIST, Gaithersburg, MD; 3Chemical Research Institute of St. Petersburg Sta, St. Petersburg, Russia “Using Comprehensive Gas Chromatographic Retention Index Collection to Aid Compound Identification from GC/MS Data” Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics; Philadelphia, PA, 2009.
“Fragmentation of Isomers of 4-keto C10H20O as a Means of Understanding EI Behavior for Purposes of Structural Elucidation of Unknowns” O. David Sparkman; Matthew Curtis; Monika Kaur; Jianhua Ren; Patrick R. Jones Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics; Philadelphia, PA, 2009.
O. David Sparkman, Patrick R. Jones, Matthew Curtis “Anatomy of Ion’s Fragmentation After Electron Ionization” Current Trends in Mass Spectrometry, Supplement to: LC·GC and Spectroscopy (Advanstar, Iselin, NJ, USA) Part 1, May 2009, P 18–29, Part II July 2009, P 12–19.
O. David Sparkman, Patrick R. Jones, Matthew Curtis Chapter 13 “Accurate Mass Measurements with a Reflectron Time-of-Flight Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for the Identification of Unknown Compounds Below Masses of 500Da” P 229–257 in Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis Imma Ferrer and E. Michael Thurman, Eds. Wiley, New York, 2009, ISBN: 978-0-470-13797-0
“Methods for Quantitative Measurements Using a Helium Metastable-Beam Open-Air Ion Source Mass Spectrometer” O. David Sparkman, Patrick R. Jones, Matthew Curtis, Teresa M. Vail Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics; Denver, CO, 2008.
“Utility of Reactions in the Source of a
Helium Metastable-Beam Open-Air Ion Source Mass Spectrometer” Matthew Curtis,
Patrick R. Jones, O. David Sparkman Proceedings
of the 56th ASMS Conference on Mass Spectrometry and Allied Topics;
“Endocrine
Disrupters Adsorbed on Macro and Micro Plastic Debris in the Ocean” Lorena M.
Rios, Patrick R. Jones, O.
David Sparkman Proceedings of the 56th
ASMS Conference on Mass Spectrometry and Allied Topics;
Co-organizer with Facundo Fernandez (Georgia Institute of Technology) at ASMS
Fall 2007 Workshop “The Art of Open Air Ionization on Surfaces” held at the
Chemical Heritage Foundation,
Presented “Harold Urey’s
Influence on Analysis by DART and DESI” at ASMS Fall 2007 Workshop,
Teresa M. Vail, O. David Sparkman, Patrick R. Jones "Rapid and Unambiguous Identification of Melamine in Contaminated Pet Food Based on Mass Spectrometry with Four Degrees of Confirmation" Journal of Analytical Toxicology 2007, 31, 304–312.
“Rapid In-Source Methods for DART-interface TOFMS Determination of Structural Information” Teresa M. Vail1; Robert B. Cody2; O. David Sparkman1; Patrick R. Jones1, 1University of the Pacific, Stockton, CA; 2JEOL USA, Inc., Peabody, MA, Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics; Indianapolis, IN, 2007.
“Direct Comparison of the H/D Exchange Rates of Methyl Group Hydrogens on Macrocyclic Ligands of Ni Complexes by Mass Spectrometry” Chang-nan Chen1; Jianhua Ren2; O. David Sparkman2; Patrick R. Jones2, 1Chaoyang University of Technology, Taichung, TAIWAN; 2University of the Pacific, Stockton, CA, Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics; Indianapolis, IN, 2007.
“A New Mass Spectrometric Method for the Assay of N8-Acetylspermidine Deacetylase” Yongyuan Zhao; James W. Blankenship; Jianhua Ren; O. David Sparkman; Patrick R. Jones, University of the Pacific, Stockton, CA, Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics; Indianapolis, IN, 2007.
“Mass Whatever! Explaining The
Significance and Impact of Mass Spectrometry in Society” Donald H. Chace1; David
Sparkman2, 1Pediatrix Analytical,
United States Patent 7,196,525 issued 3/27/2007 to O. David Sparkman and Steven M. Colby “Sample Image” using DART and DESI.
Patrick R. Jones, O. David Sparkman, Teresa Vail, Robert B. Cody, Changnan Chen “Additional Real Time Structural Information” Oral Presentation Number 2510-6, O. David Sparkman presenting, PittCon Conference & Expo 2007, March 1, 2007.
“Identification of Unknown EI Mass Spectra Using Library Searches and EI Mass Spectral Databases” in Chapter 3 “Ionization of Gas-Phase Molecules by Particles and High Temperature” Sparkman, O.D. The Encyclopedia of Mass Spectrometry, Volume 6, Fundamentals of and Applications to Organic (and Organometallic) Compounds; Michael L. Gross, Ed.; Michael L. Gross and Richard Caprioli, Editors-In-Chief; Elsevier: Oxford, U.K., 2007.
“Using Computer Aids in the Identification of
Unknown Mass Spectra Obtained with MS/MS from ESI and APCI: A Guided Tutorial”
A Web Seminar Presented through Spectroscopy,
an Advanstar Publication,
(https://online-e-events.com/Advanstar/Spectroscopy.nsf/Events/massspectra)