University of the Pacific

College of the Pacific

Department of Chemistry

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Education:

MS, PhD (under supervision of Prof. Dr. N. S. Zefirov), and Dr. of Chem. Sciences degrees from Moscow State University, Russia

Work:

1997-present: Professor, Department of Chemistry , University of the Pacific , Stockton, California, USA
1992-7: Professor and Head of Organic Chemistry Department , Moscow State Academy of Fine Chemical Technology , Russia
1974-1992: from Junior Research Scientist to Leading Research Scientist and Head of Research Group
aaaaaaaaa at the Department of Chemistry, Moscow State University , Russia

Research Interests:

Molecular switches, Conformational triggers; pH-triggers; Conformational control;
Triggerable liposomes;
Crown ethers and related compounds;
Bioactive carbohydrate mimetics; Carbohydrate processing enzymes (glycosidases)

Collaboration:

Dr. Nataliya M. Samoshina (UOP, Chemistry/Pharmacy), Dr. Andreas Franz (UOP, Chemistry), Dr. Xin Guo (UOP, Pharmacy),
Dr. Vyacheslav Chertkov (NMR Lab, MSU, Russia)

Graduate Studies and Degrees at Chemistry Department: Ph.D. and M.S.

Application for Graduate Studies
Send your complete application package to the Graduate School of the University of the Pacific.
Please, indicate clearly in your application that you want to do your graduate studies at the Department of Chemistry,
in one or both chemical tracks of PCSP program:
(1) Chemical Synthesis and Drug Discovery, and/or (2) Bioanalytical and Physical Chemistry.
Please, also send a (photo)copy of your package to the Department of Chemistry directly:
Department of Chemistry, University of the Pacific, 3601 Pacific Ave., Stockton, CA 95211, USA.
E-mail: smccann@pacific.edu; FAX: (209) 946-2607

A brief campus tour

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Molecular Switches, Conformational Triggers

Samoshin, V. V. Cyclohexane-based Conformationally Controlled Crowns and Podands.
Mini-Reviews in Organic Chemistry, 2005, 2 (3), 225-235.

Samoshin, V.V., Brazdova, B.*; Chertkov, V.A., Gremyachinsky, D.E.*, Shestakova, A.K.; Dobretsova, E.K., Vatlina, L.P.;
Yuan, J.*; Schneider, H.-J. trans-2-Aminocyclohexanols as pH-triggered molecular switches.
ARKIVOC, 2005, (iv), 129-141.

(more...)

Triggerable Liposomes

Brazdova, B.*; Zhang, N.*; Samoshin, V. V.; Guo, X.
trans-2-Aminocyclohexanol as a pH-sensitive conformational switch in lipid amphiphiles.
Chem. Commun., 2008, (39), 4774-4776.

Crown Ethers and Related Compounds

Samoshin, V. V. Cyclohexane-based Conformationally Controlled Crowns and Podands.
Mini-Reviews in Organic Chemistry, 2005, 2 (3), 225-235.

Samoshin, V. V, Chertkov, V. A., Gremyachinsky, D. E.*, Dobretsova, E. K., Shestakova, A. K.; Vatlina, L. P.
trans-2-Aminocyclohexanols as pH-triggers for conformationally controlled crowns and podands.
Tetrahedron Leters, 2004, 45 (42), 7823-7826.

Samoshin, V. V.; Troyansky, E. I.; Demchuk, D. V.*; Ismagilov, R. F.*; Chertkov, V. A.; Lindeman, S. V.; Khrustalev, V. N.; Struchkov, Yu. T.
Conformational analysis of a 12-membered crown dithioether in the solid state and in solution.
J. Phys. Org. Chem., 1998, 11, 241-253.

(more...)

Carbohydrate Mimetics, Glycosidase Inhibitors

Franz, A. H.; Gross, P. H.; Samoshin, V. V. Syntheses of small cluster oligosaccharide mimetics.
ARKIVOC, 2008, (i), 232-308.

Brazdova, B.*; Tan, N. S.*; Samoshina, N. M.; Samoshin, V. V.
Novel easily accessible glucosidase inhibitors: 4-hydroxy-5-alkoxy-1,2-cyclohexanedicarboxylic acids.
Carbohydrate Research, 2009, 344 (3), 311-321.

Gremyachinskiy, D. E.*; Samoshin, V. V.; Gross, P. H.
Total synthesis of aminomethyl-C-dideoxyglyco-pyranosides and their quinamides.
Tetrahedron Letters, 2003, 44 (35), 6587-6590.

(more...)

Carbohydrate Processing Enzymes (Glycosidases)

Samoshina, N. M.; Samoshin, V. V.
The Michaelis Constants Ratio for two substrates with a series of fungal (mould and yeast) beta-galactosidases.
Enzyme and Microbial Technology, 2005, 36 (2-3), 239-251.

(more...)

Conformational Effects

Samoshin, V. V. Cyclohexane-based Conformationally Controlled Crowns and Podands.
Mini-Reviews in Organic Chemistry, 2005, 2 (3), 225-235.

Samoshin, V. V.; Troyansky, E. I. Conformational effects in sulfur-containing six-membered cycles and macrocycles.
Phosphorus, Sulfur, and Silicon, 1997, 120/121, 181-196.

(more...)

Green Photochemistry

Samoshin, A. V.*; Samoshin, V. V.
Green photochemistry: sun-induced aromatic nucleophilic substitution of alkoxy groups by alkylamines.
J. Undergrad. Chem. Res., 2006, 5 (2), 67-70.

( * - graduate and undergraduate students at the time of research)

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Some other useless chemistry links (just for fun :)

What is Chemistry All About?
Fundamentals of Conformational Analysis
Chemical Nomenclature

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